LA RECHERCHE CLINIQUE & SHS

Cohorts

IPC cohort (Centre for Preventive and Clinical Investigation)

(in progress)

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• Context: Studies highlighting the determinants of loss of autonomy are rare. Creating a longitudinal cohort of ambulatory, autonomous patients who have consulted in an IPC center will provide more information on the determinants of the risk of loss of autonomy. 'autonomy.

• Purpose of the study : To follow a cohort of subjects aged over 65, having gone to an IPC center to carry out a Periodic Health Examination (EPS), as part of the free Periodic Health Examination offered by health insurance.

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Main objective : To highlight the determinants of the risk of loss of autonomy in non-dependent elderly subjects.

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Secondary objectives :  Closely monitor the evolution of subjects in terms of  :

- Unscheduled hospitalizations

- Occurrence of cognitive disorders and depression

- Occurrence of falls and fractures

- Occurrence of malnutrition

- Occurrence of new diseases (cancer, cardiovascular pathologies, neurological pathologies, etc.)

- Entry into an institution

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• Study methodology : Observational, prospective study.

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• Total duration of the study : 10 years

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• Location of the study  : CPI Center

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• Investigator Coordinator  : Prof. Olivier HANON, AP-HP

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• Promoter : Gérond'if

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• Funding: Gérond'if

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ELCAPA cohort (ELderly CAncer PATIENT)

(in progress)

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• context  : Validating the results of therapeutic trials on elderly subjects with cancer in order to adapt  cancer treatments for this population.

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• Purpose of the study : To follow a cohort of subjects aged 70 and over, suffering from any type of cancer, referred to a geriatrician for a standardized geriatric assessment.

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Main objective of the study: To determine the frequency of failure to carry out the cancer treatment plan and each type of treatment in elderly patients with solid cancer.

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Secondary objective  : Identify the factors associated with this non-implementation of the treatment plan, by carrying out a standardized follow-up including the collection of overall survival, disease progression, specific survival, implementation of the treatment plan, changes in the initial treatment plan, loss of autonomy, toxicities and hospitalizations...

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• Study methodology  : observational, prospective, multicenter study

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• Number of subjects included in the study  : 6000

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• Duration of the study : 15 years

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• Location of the study  : 19 UCOG from the Ile-de-France region

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• Investigator Coordinator  : Prof. Philippe CAILLET, AP-HP

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• Funding  :  INCA, UPEC, Cancéropôle d'Ile-de-France, CEPIA, Gérond'if

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INSIGHT cohort

(in progress)

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• Interest of the study : INSIGHT is an innovative study on Alzheimer's disease, and one of the first in the world to follow healthy subjects at risk. The interest of this study is to better understand the natural evolution of preclinical states (dynamic processes)  Alzheimer's disease (AD), in order to offer treatment  subjects at risk to delay the onset of clinical signs.

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• Purpose of the study : To follow more than 400 subjects, aged 75 to 85, in good health and complaining of their memory.

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Primary objective  : To analyze the differences in amyloid load between the subjects “  prodromal  » likely to progress to AD and healthy subjects.

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Secondary objectives  :

- Identify the evolution of the physiopathological process and study the early signs (abnormalities on MRI, PET or EEG, cognitive performance, disturbances in daily life, blood tests and cerebrospinal fluid biomarkers) suggestive of a MY.

- Determine the risk factors and triggers of AD

- Establish correlations between the data obtained from MRI and those from PET scans concerning the amyloid load of the participants

- Propose effective therapeutic approaches

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• Study methodology  : monocentric observational study

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• Number of subjects included  :  350

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• Duration of study : 5-6 years

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• Location of the study  : Paris, IM2A site at La Pitié-Salpêtrière Hospital

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• Coordinating Investigator : Pr. Bruno DUBOIS

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FRAGILITY cohort

(under submission)

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• Goals  of the study: Follow 2000 subjects suspected of frailty according to the questionnaire recommended by the HAS (Gérontopôle de Toulouse), included during a geriatric consultation in a prevention center or HDJ frailty.

Main objective : To highlight the clinical and biological determinants of the loss of autonomy in potentially fragile non-dependent elderly subjects.

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Secondary objectives : Highlight in these subjects;  the clinical and biological determinants of the risk of:

- Unscheduled hospitalizations

- Mortality

- Entry into an institution

- Occurrence of cognitive disorders and depression

- Occurrence of falls and fractures

- Occurrence of malnutrition

- Occurrence of new diseases (cancer, cardiovascular pathologies, neurological pathologies, etc.)

Evaluate the impact of the subjective impression of the geriatrician and the patient on the loss of autonomy

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• Study methodology: Non-interventional, multicenter, prospective study

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• Number of subjects included: 2000

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• Location: Ile-de-France

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• Total study duration: 5 years

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• Coordinating Investigator: Pr. Olivier HANON, AP-HP

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• Promoter: Gérond'if

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• Funding: Gérond'if

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  EHPAD  

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Survey on a given day on atrial fibrillation in nursing homes

(finalized)
 

• Purpose of the study  : Evaluate care practices in the population of subjects residing in nursing homes with atrial fibrillation or a history of atrial fibrillation, taking into account the numerous associated comorbidities.
   

• Methodology: Non-interventional, retrospective study.

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• Total number of subjects included: 1300

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• Location of the study: 88 EHPADs in Ile-de-France

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• Coordinating investigator:  Pr Olivier HANON, AP-HP

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• Promoter: Gérond'if

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• Funding : Gérond'if

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Night IDE study in EHPAD

(in progress)

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• Context of the project  : Since 2013, the ARS Ile-de-France has launched the IDE de nuit experiment consisting of the creation of a "mobile" night nursing position in an EHPAD with the aim of improving the continuity of care and reducing emergency hospitalizations of residents.  These nurses, employed by a "bridgehead" EHPAD, are called upon to intervene in three EHPADs identified in each department.  

This experiment aims to:  

- Improve the orientation of residents during night hours by helping to better detect risky situations, encourage the use of the SAMU Center 15 if necessary and identify avoidable emergency admissions, within the framework of pre-established procedures and in partnership with the SAMU Center 15.

- Improve the management of residents returning from hospitalization.

- Improve the continuity of care in EHPADs, by securing the teams.

- Improve the training of night staff in nursing homes.

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• Purpose of the study  : The medico-economic study launched in 2016 aims to assess  the real impact of the experimental device for shared overnight FDI in EHPADs on improving the health care pathway for the elderly.  

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Main objective: Evaluate  the real impact of the experimental device for shared overnight FDI in EHPADs on improving the health care pathway for the elderly.  

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Secondary objective: to assess the medico-economic relevance of this device (cost / utility ratio) in order to assess its interest in comparison with other modes of support at night (telephone on-call, telemedicine, HAD, etc. ).  
 

• Methodology : Controlled, non-randomized observational study, with prospective and retrospective components.

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• Duration of the research : The total duration of the study is 22 months (September 2016- June 2018)

• Scientific officer  : Professor Olivier HANON,  Broca Hospital, AP-HP    

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• Promoters : ARS Ile-de-France, Gérond'if

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• Funding: ARS Ile-de-France